Measuring flavonoids levels will help establish whether they, or other aspects, such as impaired liver functions or drugs are causative factors with vascular degeneration. Low to moderate intake of alcohol, blood thinning medications, or blood-thinning supplements & spices favorably enhance the activity of bioflavonoids, however their excessive intake not only compromises Vitamin K, but causes a noticeable drop with rutin and hesperidin levels as well... Full Text